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Li et al., 2016)

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This flood of NAD+ in the fat cells forces them to continuously burn energy rather than store it, leading to rapid reductions in fat mass without the need for dietary changes in animal models

26 An additional concern is that all present trials have been conducted in a hospital environment where drug administration is monitored

During protein folding stress, the sirtuin SIRT7 also plays an important role by contributing to repressing nuclear respiratory factor 1 (NRF1) activity, a major transcriptional regulator of mitochondrial genes